While there is some data defining normal reference values for left atrial (LA) volumes by cardiac magnetic resonance (CMR), these data have all originated from European volunteers. There are no normal reference values based on volunteers from United States (US) using the biplane area-length method. While there are data in specific subgroups, there are currently no data linking routinely derived LA volumes by CMR with overall mortality in a general clinical patient cohort. Additionally, there is a lack of categorization of severity of LA enlargement, by CMR, based on outcome data.
In this article we determine normal reference valves for LA volume using biplane area-length method using routine cine-CMR performed. We also propose partitions for mild, moderate, and severe LA enlargement based on mortality by validating the independent prognostic significance of these proposed partitions in a large multicenter cohort.
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