The evolution of LV strain after STEMI within infarcted and remote myocardium has not yet been investigated with feature-tracking CMR. Accordingly, the present sub-analysis of the METOCARD-CNIC trial evaluated the changes in regional LV peak circumferential strain with feature tracking CMR at 1 week and at 6 months after STEMI. Specifically, the effects of the early intravenous metoprolol treatment, microvascular obstruction, intramyocardial hemorrhage and adverse LV remodeling on the evolution of infarct and remote zone strain were investigated.
Reader of this article will improve their knowledge by gaining several important insights into the role of feature-tracking CMR to investigate the evolution of the infarct zone and the remote zone circumferential strain in STEMI patients.
Following this activity, readers of this article will get new insights into the evolution of regional LV systolic function (in terms of circumferential LV strain) after STEMI:
- Early intravenous metoprolol has a long-lasting cardioprotective effect on the infarct zone circumferential strain and no significant effect on the remote zone circumferential strain.
- The infarct zone circumferential strain is significantly impaired in patients with MVO and IMH, but it improves between 1 week and 6 months after STEMI regardless of the presence of MVO or IMH.
- In patients with adverse LV remodeling, defined as ≥20% increase in LV end-diastolic volume, the infarct zone circumferential strain improves but the remote zone circumferential strain worsens between 1 week and 6 months after STEMI.
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