JCMR 2020;22:86. Myocardial fibrosis in asymptomatic and symptomatic severe chronic primary mitral regurgitation and relationship to tissue characterization and LV function on cardiovascular magnetic resonance (CME)


There is a lack of knowledge regarding the presence of myocardial fibrosis in patients with chronic primary mitral regurgitation before onset of symptoms and left ventricular dysfunction. The relationship between myocardial fibrosis and imaging detection is important, as additional methods are need to optimise care and outcomes in relation to timing intervention. Awareness of the presence of fibrosis and knowledge of associated factors that may drive the fibrotic process.

The CME activity aims to narrow the knowledge gap in terms of histological evidence of myocardial fibrosis and the relationship to imaging markers.



To close the gap above:

  1. Learners need to know about the presence of myocardial fibrosis in asymptomatic and symptomatic patients with severe chronic primary MR.
  2. Learners need to know how to apply this knowledge when interpreting cardiovascular imaging and tissue characterisation in these patients.
  3. Learners need to recognise changes in tissue characterisation and associated factors in imaging these patients.


Accreditation Statement
The Society for Cardiovascular Magnetic Resonance (SCMR) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.


Credit Designation Statement
The Society for Cardiovascular Magnetic Resonance (SCMR) designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit (s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Instructions for Claiming CME

  • Read the article
  • Complete the post-activity evaluation
  • A certificate of completion will be available once the evaluation is submitted


Financial Disclosures
The planners and faculty for this activity did not have any financial disclosures.


Disclosure of Commercial Support

This activity received no commerical support.



  1. Liu B, Edwards NC, Pennell D, Steeds RP: The evolving role of cardiac magnetic resonance in primary mitral regurgitation: ready for prime time? European heart journal cardiovascular Imaging 2019, 20(2):123-130.
  2. Fuster V, Danielson MA, Robb RA, Broadbent JC, Brown AL, Elveback LR: Quantitation of left-ventricular myocardial fiber hypertrophy and interstitial-tissue in human hearts with chronically increased volume and pressure overload. Circulation 1977, 55(3):504-508.
  3. Edwards NC, Moody WE, Yuan MS, Weale P, Neal D, Townend JN, Steeds RP: Quantification of Left Ventricular Interstitial Fibrosis in Asymptomatic Chronic Primary Degenerative Mitral Regurgitation. Circ-Cardiovasc Imaging 2014, 7(6):946-953.
  4. Kitkungvan D, Nabi F, Kim RJ, Bonow RO, Khan MA, Xu JQ, Little SH, Quinones MA, Lawrie GM, Zoghbi WA et al: Myocardial Fibrosis in Patients With Primary Mitral Regurgitation With and Without Prolapse. J Am Coll Cardiol 2018, 72(8):823-834
Course Information
Course Date:
September 30, 2020
Individual topic purchase: Selected
Accreditation Council For Continuing Medical Education
AMA PRA Category 1 Credit(s)™: 1.00
SCMR Member Price:$0.00
Non-Member Price:$10.00